Hope Davis

It is 1964: Bert Cousins shows up at Franny Keating's christening party uninvited and notices a heart stoppingly beautiful woman. When he kisses Beverly Keating, his host's wife, he sets in motion the joining of two families, whose shared fate will be defined on a day seven years later.

In 1988, Franny Keating, now twenty-four, is working as a cocktail waitress in Chicago. When she meets the famous author Leon Posen one night at the bar, and tells him about her family, she unwittingly relinquishes control over their story…

Among the tangled waterways and giant anacondas of the Brazilian Rio Negro, an enigmatic scientist is developing a drug that could alter the lives of women for ever.

Dr Annick Swenson's work is shrouded in mystery; she refuses to report on her progress, especially to her investors, whose patience is fast running out.

Anders Eckman, a mild-mannered lab researcher, is sent to investigate. A curt letter reporting his untimely death is all that returns. Now Marina Singh, Anders' colleague and once a student of the mighty Dr Swenson, is their last hope.

Compelled by the pleas of Anders's wife, Marina leaves the snowy plains of Minnesota and retraces her friend's steps into the heart of the South American darkness, determined to track down Dr. Swenson and uncover the secrets being jealously guarded among the remotest tribes of the rainforest.